Product details
MERISCREEN® Dengue Onset — Complete Dengue Diagnosis From Day 1 in a Single Kit
MERISCREEN® Dengue Onset is a 3-in-1 rapid combo test that combines NS1 Antigen detection with IgG/IgM antibody differentiation in a single kit — providing complete dengue diagnostic coverage from Day 1 of fever through convalescence. One kit, one patient, one definitive answer across all stages of infection.
Dengue Onset = Dengue NS1 Ag + Dengue IgG/IgM Ab
Why a Combo Test?
Dengue presents a diagnostic challenge because different markers appear at different stages. NS1 antigen is detectable from Day 1 through Day 9, while IgM antibodies appear from Day 5 onwards and IgG from Day 14 (primary) or Day 2 (secondary). Patients rarely present on a predictable day of illness — a combo test eliminates the guesswork by covering the entire diagnostic window simultaneously. This is especially critical during peak season when fever clinics see hundreds of patients daily and need rapid, one-shot answers.
How It Works
Each test set contains two cassettes — one for NS1 antigen detection (using monoclonal antibody capture and colloidal gold conjugate) and one for IgG/IgM antibody differentiation (using GAC and MAC principles with recombinant dengue envelope proteins). Both cassettes use the same assay buffer. Add 90–100 µL serum/plasma to the NS1 device via dropper, and 5 µL to the IgG/IgM device via capillary tube. Read results at 20 minutes. All four serotypes (DEN-1, DEN-2, DEN-3, DEN-4) are detected across both cassettes.
Key Advantages
- Complete Coverage: Detects dengue at every stage — NS1 for acute phase (Day 1–9), IgM for primary infection (Day 5+), IgG for secondary infection (Day 2+)
- Primary vs. Secondary Differentiation: Dual antibody lines distinguish primary dengue (IgM dominant) from secondary dengue (IgG dominant) — critical for DHF/DSS risk stratification
- All 4 Serotypes: Both cassettes detect DEN-1, DEN-2, DEN-3, DEN-4
- Cost-Effective: Single combo kit replaces purchasing NS1 and IgG/IgM kits separately — saves procurement cost and storage space
- Rapid Results: Both results in 20 minutes — no instruments, no electricity
- High Performance: Sensitivity ≥95%, Specificity ≥95% on both cassettes
- Robust Storage: 2–30°C — no cold chain dependency
Clinical Applications
- First-line diagnostic in fever OPDs and emergency departments — one kit answers "Is it dengue?" and "Primary or secondary?" simultaneously
- High-throughput screening during dengue season (July–November) — reduces per-patient test turnaround
- Clinical triage for DHF/DSS risk — secondary infections (IgG+) carry higher risk of hemorrhagic complications
- Pathology labs and diagnostic chains seeking a single-SKU dengue solution
- Government NVBDCP surveillance and outbreak response
- PHCs and rural health centers where stocking multiple separate kits is impractical
Diagnostic Window Coverage
| Day of Illness | NS1 Ag | IgM Ab | IgG Ab (Primary) | IgG Ab (Secondary) |
| Day 1–4 | ✅ Detectable | ❌ Not yet | ❌ Not yet | ✅ Day 2+ |
| Day 5–9 | ✅ Detectable | ✅ Appears | ❌ Not yet | ✅ Rising |
| Day 10–14 | ⚠️ Declining | ✅ Peak | ✅ Appears | ✅ High |
| Day 15+ | ❌ Gone | ✅ Persists 30–60d | ✅ Persists | ✅ Persists |
The Dengue Onset combo covers every row in this table — no diagnostic blind spots.
Product Specifications
| SKU | RPDDON-01 |
| Pack Size | 10 Tests (10 NS1 cassettes + 10 IgG/IgM cassettes) |
| Assay Format | Dual-Cassette Rapid Immunochromatographic Assay (Lateral Flow) |
| Detection Targets | NS1 Antigen + Anti-Dengue IgG (GAC) + Anti-Dengue IgM (MAC) |
| Serotype Coverage | DEN-1, DEN-2, DEN-3, DEN-4 |
| Sample Type | Serum, Plasma |
| Sample Volume | NS1: 90–100 µL (dropper) | IgG/IgM: 5 µL (capillary tube) |
| Assay Buffer | 4 drops (shared buffer for both cassettes) |
| Result Time | 20 minutes |
| Sensitivity | ≥95% |
| Specificity | ≥95% |
| Storage | 2–30°C (no cold chain required) |
| HSN Code | 3006 |
| GST | 5% (inclusive in listed price) |
| Manufacturer | Meril Diagnostics Pvt. Ltd., India |
Kit Contents
- 10 NS1 Ag test cassettes (individually sealed)
- 10 IgG/IgM Ab test cassettes (individually sealed)
- 10 droppers (for NS1) + 10 capillary tubes (for IgG/IgM)
- 2 bottles assay buffer (shared)
- 1 package insert / IFU
Interpretation Guide
| NS1 Result | IgG/IgM Result | Interpretation |
| NS1 Positive | IgM/IgG Negative | Early acute dengue (Day 1–4) — active viremia, monitor platelet count |
| NS1 Positive | IgM Positive | Acute primary dengue — seroconversion underway |
| NS1 Positive | IgG Positive | Acute secondary dengue — HIGH DHF/DSS risk, close monitoring |
| NS1 Negative | IgM Positive | Primary dengue, post-viremic phase (Day 5+) |
| NS1 Negative | IgG + IgM Positive | Secondary dengue, convalescent — monitor for DHF |
| NS1 Negative | IgG Positive only | Past dengue exposure or late secondary infection |
| NS1 Negative | All Negative | Dengue unlikely — consider other differentials |
Why Buy From Agile Healthcare?
- Authorized Meril Diagnostics master distributor — genuine stock with batch traceability
- GST-inclusive pricing — no hidden charges
- Volume discounts: 10% off at 5+ boxes, 18% off at 10+, 27% off at 25+
- Pan-India delivery within 3–5 business days
- Technical support and application training available
- Certificate of Analysis (CoA) available on request
- Also available separately: NS1 Ag (RPDDAG-01) and IgG/IgM (RPDDAB-01)