Product details
MERISCREEN® Dengue NS1 Ag — Early Detection From Day 1 of Fever
MERISCREEN® Dengue NS1 Ag is a one-step, rapid immunochromatographic assay for the qualitative detection of Dengue NS1 antigen in human serum or plasma. NS1 antigen is detectable from Day 1 of fever onset through Day 9 — before antibodies appear — making this the frontline test for early dengue diagnosis and clinical triage.
How It Works
The test cassette uses monoclonal antibodies specific to Dengue NS1 antigen, conjugated with colloidal gold. When 90–100 µL of patient serum/plasma is applied via the dropper, NS1 antigen (if present) binds to the anti-NS1 gold conjugate, forming an antigen-antibody complex. This complex migrates along the membrane and is captured at the test line, producing a visible pink/red band within 20 minutes. A procedural control line validates each test. No sample preparation, no instruments, no electricity required.
Key Advantages
- Day 1 Detection: NS1 antigen appears within 24 hours of fever onset — the earliest serological marker for dengue, detectable before IgM/IgG seroconversion
- All 4 Serotypes: Detects NS1 from DEN-1, DEN-2, DEN-3, and DEN-4 using monoclonal antibody capture
- High Performance: Sensitivity ≥95%, Specificity ≥95% — comparable to ELISA-based NS1 at a fraction of the cost and turnaround
- No Sample Prep: Direct application of serum/plasma — no centrifugation, dilution, or pre-treatment steps
- Rapid Results: Visual read at 20 minutes — ideal for high-throughput fever clinics and emergency settings
- Extended Shelf Life: 24 months at 2–30°C — superior stability for tropical supply chains and remote field deployment
Clinical Applications
- First-line screening in fever OPDs, emergency departments, and PHCs during dengue season (July–November)
- Early diagnosis from Day 1–9 of fever — before antibody window opens
- Pre-seroconversion detection — critical for initiating fluid management and platelet monitoring early
- NVBDCP sentinel surveillance and outbreak response programs
- Blood bank screening in dengue-endemic regions
- Complement to IgG/IgM testing (RPDDAB-01) for complete dengue diagnostic coverage across all fever days
When to Use This Test
NS1 antigen is the earliest detectable marker for dengue — present from Day 1 and persisting up to Day 9 after fever onset. It is most effective during the acute febrile phase (Day 1–7) before the immune system produces detectable antibodies. For patients presenting after Day 5, combine with IgG/IgM antibody testing (RPDDAB-01) to cover the full diagnostic window. For complete Day 1 coverage through convalescence, use the Dengue Onset combo (RPDDON-01) which combines NS1 Ag + IgG/IgM in a single cassette.
Product Specifications
| SKU | RPDDAG-01 |
| Pack Size | 10 Tests |
| Assay Format | Rapid Immunochromatographic Assay (Lateral Flow) |
| Detection Target | Dengue NS1 Antigen (Non-Structural Protein 1) |
| Serotype Coverage | DEN-1, DEN-2, DEN-3, DEN-4 |
| Sample Type | Serum, Plasma |
| Sample Volume | 90–100 µL (2 drops via dropper) |
| Result Time | 20 minutes |
| Sensitivity | ≥95% |
| Specificity | ≥95% |
| Storage | 2–30°C (no cold chain required) |
| Shelf Life | 24 months |
| HSN Code | 3006 |
| GST | 5% (inclusive in listed price) |
| Manufacturer | Meril Diagnostics Pvt. Ltd., India |
Kit Contents
- 10 individually sealed test cassettes
- 10 droppers / micropipettes
- 1 bottle assay buffer
- 1 package insert / IFU
Interpretation Guide
| Result | Lines Visible | Interpretation |
| Negative | C only | No detectable NS1 antigen — does not rule out dengue (test IgG/IgM if Day 5+) |
| Positive | C + T | Active dengue infection confirmed — initiate clinical management |
| Invalid | No C line | Test failed — repeat with a new cassette |
Why Buy From Agile Healthcare?
- Authorized Meril Diagnostics master distributor — genuine stock with batch traceability
- GST-inclusive pricing — no hidden charges
- Volume discounts: 10% off at 5+ boxes, 18% off at 10+, 27% off at 25+
- Pan-India delivery within 3–5 business days
- Technical support and application training available
- Certificate of Analysis (CoA) available on request